There are nearly as many noise removal software applications as there are sharpening ones; Digital Outback Photo have just reviewed another new tool called Helicon Filter Pro:

“The best known noise removal tools today are Neat Image and Noise Ninja. A couple of months ago we got a first version of the Helicon Filter and followed the betas since then. Besides the very good results we like the following features:

Large preview to judge the noise removal effect
Easy to use
Hardly any plastic look and only minor softening of the image
Control of shadow, midtone and highlight noise removal
Photoshop plugin”

Website: Digital Outback Photo - Helicon Filter Pro Review